Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 50, Issue 1, Pages 1-14Publisher
SPRINGER
DOI: 10.1007/s00249-021-01496-7
Keywords
Collective cell migration; Cell speed; Viscoelasticity of cellular domains; Residual stress accumulation; Jamming state transition
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Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2020-14/200135]
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Collective cell migration (CCM) is a highly coordinated migratory mode, with a focus on the impact of cellular rearrangements and multi-scale quantitative approaches to understand this process.
Collective cell migration (CCM), a highly coordinated and fine-tuned migratory mode, is involved in a plethora of biological processes, such as embryogenesis, tissue repair and cancer invasion. Although a good comprehension of how cells collectively migrate by following molecular rules has been generated, the impact of cellular rearrangements on collective migration remains less understood. Thus, considering CCM from a multi-scale quantitative approach could result in a powerful tool to address the contribution of cellular rearrangements in CCM and help to understand this important but still controversial topic. In this work, a review of existing literature in CCM modeling at different scales is given along with assortment of published experimental findings, to invite experimentalists to test given theoretical considerations in multicellular systems. In addition, three different time and space scales (free or weakly connected cells, cluster of cells and collision fronts of different cells clusters) are considered and the multi-scale nature of those processes was discussed with special emphasis of jamming and unjamming states.
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