Journal
EPILEPSIA
Volume 62, Issue 3, Pages 563-569Publisher
WILEY
DOI: 10.1111/epi.16823
Keywords
ALF; epilepsy; hippocampus; memory consolidation; NREM sleep
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Accelerated long-term forgetting (ALF) is a specific form of amnesia commonly seen in patients with focal epilepsy, especially temporal lobe epilepsy. Researchers have proposed a pathophysiological model of ALF that integrates the role of interictal spikes to explain the mechanisms of ALF occurring at different time scales.
Accelerated long-term forgetting (ALF) is a particular form of amnesia mostly encountered in focal epilepsy, particularly in temporal lobe epilepsy. This type of memory loss is characterized by an impairment of long-term consolidation of declarative memory, and its mechanisms remain poorly understood. In particular, the respective contribution of lesion, seizures, interictal epileptic discharges, and sleep is still debated. Here, we provide an overview of the relationships intertwining epilepsy, sleep, and memory consolidation and, based on recent findings from intracranial electroencephalographic recordings, we propose a model of ALF pathophysiology that integrates the differential role of interictal spikes during wakefulness and sleep. This model provides a framework to account for the different timescales at which ALF may occur.
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