Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 81, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.etap.2020.103537
Keywords
Invertebrates; Aquatic toxicology; Pharmaceutical compounds; Emergent contaminants; Molecular response; Chironomus
Funding
- Programa Estatal de I+D+i Orientada a los Retos de la Sociedad (Spain) from the Ciencias y Tecnologias Medioambientales program [RTI2018-094598-B-I00]
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This study found that ibuprofen at environmental concentrations had significant effects on the survival, transcriptional levels, and enzymatic activity of Chironomus riparius. The results confirmed alterations on the development of C. riparius and essential mechanisms involved in protection against toxicological challenges. Ibuprofen poses a potential risk to C. riparius by compromising their survival, development, and ability to respond to adverse conditions.
The concern about pharmaceuticals has been increased over the last decade due to their burgeoning consumption. Ibuprofen has an extensive presence in surface water with risks for the aquatic biota. This study focuses on the effects of ibuprofen at environmental concentrations on the survival, transcriptional level, and enzymatic activity for 24, 96 h on Chironomus riparius. Ibuprofen developed a substantial effect on survival by all the conditions. mRNA levels of EcR, Dronc, and Met (endocrine system), hsp70, hsp24, and hsp27 (stress response), and Proph and Def (immune system) were modified, joined to increased GST and PO activity. The results confirmed alterations on the development of C. riparius, as well as two essential mechanisms, involved in protection against external toxicological challenge. Ibuprofen poses an incipient risk to C. riparius and could at an organismal level by compromising their survival, development, and ability to respond to adverse conditions on the future populations.
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