Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume 55, Issue 2, Pages 1099-1109Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.0c03758
Keywords
-
Categories
Funding
- Priority Research Program of the Shandong Academy of Sciences
- Special Foundation of Taishan Scholars
- Shandong Provincial Natural Science Foundation [ZR2016YL013, ZR2015YL005, 2017GSF19111]
- National Natural Science Foundation of China (NSFC) [81600692, 81970759, 81803539]
- Youth Science Funds of Shandong Academy of Sciences [2018QN003]
- Six Talent Peaks Project in Jiangsu Province [2017-WSN-186]
- Bellbery-Viertel Senior Medical Research Fellowship
Ask authors/readers for more resources
Recent research has shown that the chlorinated flame-retardant dechlorane 602 exacerbates airway inflammation in mice models induced by house dust mite or IL-33. The effects are linked to increased production of type 2 cytokines and proinflammatory cytokines, providing important immunological insights for further studies on the health impact of emerging flame-retardant dechloranes including Dec 602.
Chlorinated flame-retardant dechloranes are emerging substitutes for restricted flame retardants. Recent studies have demonstrated that they are accumulated in wildlife and detectable in humans; however, their effects on human health are poorly understood. Here, for the first time, we revealed that widely used chlorinated flame-retardant dechlorane 602 (Dec 602) exacerbated airway inflammation in two mouse models induced by house dust mite (HDM) or IL-33, respectively. Deteriorated airway inflammation by Dec 602 was associated with a higher production of type 2 cytokines including IL-4, IL-5, and IL-13, and IgE, accompanied by enhanced mRNA expression of proinflammatory cytokines such as TNF-alpha and IL-6. Mechanistically, we found that Dec 602 directly potentiated mouse and human group 2 innate lymphoid cells and, as such, promoted airway inflammation even in the absence of conventional T cells in Rag(-/-) mice. These findings provide novel immunological insights necessary for further studies of the health impact of emerging flame-retardant dechloranes including Dec 602.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available