Journal
ENVIRONMENTAL POLLUTION
Volume 267, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.115610
Keywords
Cadmium; Yeast-Se; Nano-Se; Sodium selenite; Testicular dysfunction
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Funding
- National Natural Science Foundation of China [31572586]
- Excellent Youth Foundation of Heilongjiang Province of China [JC2017005]
- China Agriculture Research System [CARS-35]
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Cadmium (Cd), a major environmental contaminant, is closely associated with male reproductive health. Selenium (Se) has been recognized as an effective chemo-protectant against Cd toxicity, but the underlying mechanisms remain unclear. The objective of present study was to illustrate the toxic effect of Cd on testis, and then compare the antagonistic effect among different Se sources on growth performance, testicular damage, ion homeostasis, antioxidative potential, and the expression of selenotranscriptome and biosynthetic related factors in Cd-treated chicken. Male chickens were fed with (I) Control group: basal diet; (II) Cd group: basal diet with 140 mg/kg CdCl2; (III) YSe + Cd group: basal diet with 140 mg/kg CdCl2 and 3 mg/kg Yeast-Se; (IV) NSe + Cd group: basal diet with 140 mg/kg CdCl2 and 1 mg/ kg Nano-Se; (V) SSe + Cd group: basal diet with 140 mg/kg CdCl2 and 3 mg/kg Na2SeO3. It was observed that different Se treatments dramatically alleviated Cd-induced testicular developmental disorder, ion homeostasis disorder, hormone secretion disorder and oxidative stress. Simultaneously, Se mitigated Cdinduced testicular toxicity by regulating selenoprotein biosynthetic related factors to promote selenoprotein transcription. Finally, this study indicated that dietary supplementation of Yeast-Se produced an acceptable Se form to protect testis from Cd exposure. (C) 2020 Elsevier Ltd. All rights reserved.
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