Journal
ENVIRONMENTAL POLLUTION
Volume 269, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.116158
Keywords
Polycyclic aromatic hydrocarbon; Papillary thyroid carcinoma; Nodular goiter; Risk assessment
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81973081]
- Natural Science Foundation of Liaoning Province, China [2019JH3/10300408]
- Liaoning Revitalization Talents Program [XLYC1807225]
- Shenyang Young and Middle-aged Science and Technology Innovation Talents Support Program [RC200419]
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Exposure to polycyclic aromatic hydrocarbons (PAHs) may increase the risk of thyroid nodular goiter (NG)/papillary thyroid carcinoma (PTC), with a gender-specific effect observed. Elevated concentrations of specific OH-PAHs in NG and PTC patients are associated with increased disease risk.
Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to the development of certain diseases. However, the relationship between PAH exposure and thyroid disorders remains unknown. We measured 10 of the most common hydroxylated PAHs (OH-PAHs) in the urine of thyroid nodular goiter (NG) patients, papillary thyroid carcinoma (PTC) patients, and healthy controls by gas chromatographytriple-quadrupole mass spectrometry (GC-MS/MS). We found that the concentrations of 2-hydroxyfluorene (2-OH-FLU), 2-hydroxydibenzofuran (2-OH-DBF), and 1-hydroxyphenanthrene (1-OH-PHE) in the NG group, and of 2-hydroxynaphthalene (2-OH-NAP), 2-OH-DBF, and 1-OH-PHE in the PTC group were significantly higher than those in controls. In addition, participants in the high tertiles of 2-OH-FLU and 1-OH-PHE had higher risk of NG. Besides these two OH-PAHs, elevated risk of NG was observed in women in the high tertiles of 1-hydroxynaphthalene (1-OH-NAP), 2-OH-NAP, 2-OH-DBF, and 3-hydroxyfluorene (3-OH-FLU). Furthermore, participants in the high tertiles of seven OH-PAHs, namely, 1-OH-NAP, 2-OH-NAP, 2-OH-DBF, 2-OH-FLU, 3-OH-FLU, 3/9-hydroxyphenanthrene (3/9-OH-PHE), and 1-OH-PHE, had elevated risk of PTC, and females in these high tertiles had an even higher risk of PTC. Our findings suggest that PAH exposure may increase the risk of NG/PTC, and there may be a gender-specific effect of PAH exposure on the development of NG/PTC. (C) 2020 Elsevier Ltd. All rights reserved.
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