Journal
ENVIRONMENTAL POLLUTION
Volume 268, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2020.115809
Keywords
Xenopus; Toxicity; Toxicant; Oocyte; Embryo development; Disease model
Categories
Funding
- National Nature Sciences Foundation of China [NSFC 31871041]
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The Xenopus model is advantageous for studying embryo development and developmental toxicity, as well as human diseases. It has been successfully used to study various diseases, including fetal alcohol spectrum disorders, autism, epilepsy, and cardiovascular disease. Xenopus also has potential applications in genetic and chemical screening.
The Xenopus model offers many advantages for investigation of the molecular, cellular, and behavioral mechanisms underlying embryo development. Moreover, Xenopus oocytes and embryos have been extensively used to study developmental toxicity and human diseases in response to various environmental chemicals. This review first summarizes recent advances in using Xenopus as a vertebrate model to study distinct types of tissue/organ development following exposure to environmental toxicants, chemical reagents, and pharmaceutical drugs. Then, the successful use of Xenopus as a model for diseases, including fetal alcohol spectrum disorders, autism, epilepsy, and cardiovascular disease, is reviewed. The potential application of Xenopus in genetic and chemical screening to protect against embryo deficits induced by chemical toxicants and related diseases is also discussed. (C) 2020 Elsevier Ltd. All rights reserved.
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