Journal
DEVELOPMENTAL BIOLOGY
Volume 420, Issue 2, Pages 251-261Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2016.06.039
Keywords
Organoid; 3D cultures; Pancreas; Liver; Niche signals; Stem cell
Categories
Funding
- Herchel Smith Fund
- Wellcome Trust Four-Year PhD Studentship
- Wellcome Cambridge Trust Scholarship
- Wellcome Trust [104151/Z/14/Z]
- Royal Society [104151/Z/14/Z]
- Stem Cell Biology and Medicine Programme
- Wellcome Trust [104151/Z/14/Z] Funding Source: Wellcome Trust
- Medical Research Council [MC_PC_12009] Funding Source: researchfish
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The liver and pancreas are critical organs maintaining whole body metabolism. Historically, the expansion of adult-derived cells from these organs in vitro has proven challenging and this in turn has hampered studies of liver and pancreas stem cell biology, as well as being a roadblock to disease modelling and cell replacement therapies for pathologies in these organs. Recently, defined culture conditions have been described which allow the in vitro culture and manipulation of adult-derived liver and pancreatic material. Here we review these systems and assess their physiological relevance, as well as their potential utility in biomedicine. (C) 2016 Elsevier Inc. All rights reserved.
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