Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 58, Issue 5, Pages 437-445Publisher
WILEY
DOI: 10.1111/dgd.12293
Keywords
Fgf8 signaling; hindbrain; isthmus; midbrain; Pea3; Ras-ERK
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Funding
- Grants-in-Aid for Scientific Research [26430033] Funding Source: KAKEN
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In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras-ERK pathway to specify hindbrain. Downstream of ERK, Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.
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