Journal
DEVELOPMENT
Volume 143, Issue 16, Pages 2882-2897Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.128892
Keywords
Gene expression; Chromatin remodeling; Chromatin remodeler; Transcription; Differentiation
Categories
Funding
- National Institutes of Health National Heart, Lung, and Blood Institute (NHLBI) [UM1 HL098179, P01 HL089707]
- Tobacco-Related Disease Research Program [22FT-0079]
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Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These complexes contain diverse subunits that together provide a multitude of functions, from early embryogenesis through cell differentiation and development into various adult tissues. Here, we review the functions of chromatin remodelers and their different subunits during mammalian development. We discuss the mechanisms by which chromatin remodelers function and highlight their specificities during mammalian cell differentiation and organogenesis.
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