Journal
DEVELOPMENT
Volume 143, Issue 13, Pages 2261-2272Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.135400
Keywords
Absorptive surface; Intestinal lengthening; Mesenchymal clusters; Microvillus inclusion disease; Short bowel syndrome; Villus morphogenesis
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Funding
- National Institutes of Health [R01 DK089933, F30 DK100125]
- American Society for Parenteral and Enteral Nutrition Rhoads Research Foundation
- University of Michigan Gastrointestinal Peptide Center Pilot Feasibility Award [NIDDK/NIH Research Core Grant] [P30 DK034933]
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The vertebrate small intestine requires an enormous surface area to effectively absorb nutrients from food. Morphological adaptations required to establish this extensive surface include generation of an extremely long tube and convolution of the absorptive surface of the tube into villi and microvilli. In this Review, we discuss recent findings regarding the morphogenetic and molecular processes required for intestinal tube elongation and surface convolution, examine shared and uniqueaspects of theseprocesses in different species, relate these processes to known human maladies that compromise absorptive function and highlight important questions for future research.
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