Journal
DEVELOPMENT
Volume 143, Issue 14, Pages 2494-2510Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.092163
Keywords
Conversion; Direct reprogramming; Neurogenesis; Neuron; Neuronal subtype; Transdifferentiation; Transcription factor
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Funding
- European Research Council [340793]
- Bavarian Research Network ForIPs
- Helmholtz Association
- Deutsche Forschungsgemeinschaft
- [Sonderforschungsbereich (SFB) 870]
- European Research Council (ERC) [340793] Funding Source: European Research Council (ERC)
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The key signalling pathways and transcriptional programmes that instruct neuronal diversity during development have largely been identified. In this Review, we discuss how this knowledge has been used to successfully reprogramme various cell types into an amazing array of distinct types of functional neurons. We further discuss the extent to which direct neuronal reprogramming recapitulates embryonic development, and examine the particular barriers to reprogramming that may exist given a cell's unique developmental history. We conclude with a recently proposed model for cell specification called the 'Cook Islands' model, and consider whether it is a fitting model for cell specification based on recent results from the direct reprogramming field.
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