Resveratrol alleviates zea-induced decidualization disturbance in human endometrial stromal cells

Decidualization, which endows the endometrium competency to adopt developing embryo and maintain appropriate milieu for following growth, is a pivotal process for human pregnancy. The delicate collaboration between ovarian steroid hormones estrogen and progesterone governs the process of decidualization and sub-sequent establishment of embryo implantation. Mycotoxin zearalenone (ZEA) is well known as endocrine disruptor due to its potent estrogenic activity. In this study, we investigated effects of ZEA on decidualization of human endometrial stromal cells. Results indicated that ZEA exhibited its inhibitory action through nuclear translocation of ER alpha. ZEA exposure led to dampened progress of decidualization, which could be attenuated by estrogen receptor antagonist. Notably, resveratrol (RSV) administration restored impaired decidualization process by induction of anti-oxidative gene glutathione peroxidase 3 (GPX3). This study provides novel insights into the mechanism underlying adverse effects of ZEA in human decidual stromal cells and suggests RSV a potential therapeutic candidate to alleviate ZEA-induced cytotoxicity during decidualization.

Automated summary

This study investigated the effects of the mycotoxin zearalenone on decidualization of human endometrial stromal cells, revealing that ZEA inhibits the decidualization process through nuclear translocation of ER alpha. However, this inhibitory effect can be attenuated by an estrogen receptor antagonist, and resveratrol administration can restore impaired decidualization by inducing the antioxidative gene GPX3.