Journal
DEVELOPMENT
Volume 143, Issue 6, Pages 924-935Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.132431
Keywords
Endothelial; Lymphatic; Embryonic origin; Venous
Categories
Funding
- Marie Curie Actions-International Reintegration grants [FP7-PEOPLE-2009-RG 256393]
- European Research Council [335605]
- Minerva Foundation [711128]
- Willner Family Center for Vascular Biology
- estate of Paul Ourieff
- Carolito Stiftung
- Lois Rosen, Los Angeles, CA, USA
- Fondazione Henry Krenter
- Wallach Hanna & Georges Lustgarten Fund
- Polen Charitable Trust
- European Research Council (ERC) [335605] Funding Source: European Research Council (ERC)
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The lymphatic system is a blind-ended network of vessels that plays important roles in mediating tissue fluid homeostasis, intestinal lipid absorption and the immune response. A profound understanding of the development of lymphatic vessels, as well as of the molecular cues governing their formation and morphogenesis, might prove essential for our ability to treat lymphatic-related diseases. The embryonic origins of lymphatic vessels have been debated for over a century, with a model claiming a venous origin for the lymphatic endothelium being predominant. However, recent studies have provided new insights into the origins of lymphatic vessels. Here, we review the molecular mechanisms controlling lymphatic specification and sprouting, and we discuss exciting findings that shed new light on previously uncharacterized sources of lymphatic endothelial cells.
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