Journal
DEVELOPMENT
Volume 143, Issue 23, Pages 4291-4300Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.139071
Keywords
EMT; Collective migration; Epithelial; Mesenchymal
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Funding
- Spanish Ministerio de Economia y Competitividad (MINECO)
- Generalitat de Catalunya
- Severo Ochoa Award of Excellence from MINECO (Government of Spain)
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During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively as epithelial cells, or undergo an epithelial-to-mesenchymal transition and migrate as individual mesenchymal cells. Here, we assess what is currently known about in vivo cell migratory phenomena and hypothesise that such migratory behaviours do not fit into alternative and mutually exclusive categories. Rather, we propose that these categories can be viewed as the most extreme cases of a general continuum of morphological variety, with cells harbouring different degrees or combinations of epithelial and mesenchymal features and displaying an array of migratory behaviours.
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