Development of indole-based fluorescent probe for detection of fluoride and cell imaging of HepG2

A fluorescent probe IDS based on indole ring was designed and synthesized. It has been successfully developed for highly selective detection of fluoride ions with a low detection of 1.3 ppb. Besides, the probe IDS was used for fluorescence imaging of F- in HepG2 cells and detected the concentration of fluoride ions in the environmental water samples and urine sample. These applications suggested that IDS was a sensitive probe in research and potential for the diagnosis of endemic fluorosis.

Automated summary

The fluorescent probe IDS based on the indole ring was successfully designed and synthesized for selective detection of fluoride ions, with a low detection limit of 1.3 ppb. It was used for fluorescence imaging of F- in HepG2 cells and for detecting fluoride ion concentrations in environmental water samples and urine samples. These applications indicate that IDS is a sensitive probe with potential for research and the diagnosis of endemic fluorosis.