Journal
DYES AND PIGMENTS
Volume 184, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2020.108854
Keywords
Xanthene-cyanine dye; Iodinated dye; Photosensitizer; Antimicrobial photodynamic therapy; APDT; Staphylococcus aureus
Funding
- Israel Scientific Foundation (ISF) [810/18]
- Ariel University, Isreal
- FAU project [RA2000000056]
- Center for Absorption in Science of the Ministry of Immigrant Absorption of Israel
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The study introduces new NIR photosensitizers based on iodinated xanthene-cyanine dyes, which exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration and NIR light dose.
Photosensitizers (PSs) are chemical entities that upon light exposure are able to produce cytotoxic species such as singlet oxygen superoxide and free radicals. PSs are used in photodynamic therapy applications (PDT) to eradicate cancer cells, pathogenic bacteria, fungi, and viruses. Development of the NIR-activatable photosensitizes with high phototoxicity and low toxicity in dark conditions is challenging. Here we first report on the synthesis and antimicrobial testing of the new NIR photosensitizers based on the iodinated xanthene-cyanine dyes. These new photosensitizers exhibit high antimicrobial efficacy on Staphylococcus aureus pathogens at low dye concentration (similar to 0.5 mu M) and low NIR light dose (24.3 J/cm(2)).
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