Journal
DRUG DISCOVERY TODAY
Volume 26, Issue 4, Pages 993-1005Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2020.12.021
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Funding
- DBT-RA Program in Biotechnology and Life Sciences
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This review discusses the anticancer potential of Indian snake venom toxins, highlighting the need for further research and development to successfully translate these findings into clinically available anticancer drug prototypes.
The limitations and adverse effects of current anticancer therapies have prompted the exploration for novel and relatively safer anticancer drugs from natural sources. India has a rich diversity of venomous snake fauna and, over the past two decades, several studies have demonstrated the anticancer potential of Indian snake venoms and their isolated components in cancer cell lines and animal tumor models. Nevertheless, anticancer drug prototypes derived from Indian snake venoms are not currently clinically available. In this review, we discuss the anticancer potential of Indian snake venoms toxins, and provide a critical analysis of the associated investigations for the successful development of candidate venom toxins as anticarcinogenic drug prototypes in clinical settings.
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