Journal
DNA AND CELL BIOLOGY
Volume 40, Issue 1, Pages 116-125Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2020.5983
Keywords
aquaporin; pregnancy complications; expression; regulation
Funding
- National Natural Science Foundation of China [81601319, 18331201]
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Aquaporins are small hydrophobic integral membrane proteins that facilitate rapid transport of water and small solutes. Abnormal expressions of AQPs are linked to various pregnancy complications and reproductive dysfunctions, making them potential therapeutic targets for related diseases.
Aquaporins (AQPs), small hydrophobic integral membrane proteins, mediate rapid transport of water and small solutes. The abnormal expressions of AQPs are associated with pregnancy complications and reproductive dysfunctions, including preeclampsia, gestational diabetes mellitus, tubal ectopic pregnancy, intrahepatic cholestasis of pregnancy, preterm birth, chorioamnionitis, polyhydramnios, and oligohydramnios, thus resulting in adverse pregnancy outcomes. This review explains the alterations of AQPs in pregnancy complications and reproductive dysfunctions and summarizes the molecular mechanisms involved in the regulations of AQPs by drugs such as oxytocin, polychlorinated biphenyls, all-trans-retinoic acid, salvia miltiorrhiza, and insulin, or other factors such as oxygen and osmotic pressure. All the researches provide evidence that AQPs could be the new therapeutic targets of pregnancy-related diseases.
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