Journal
DEVELOPMENT
Volume 143, Issue 10, Pages 1644-1648Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.132928
Keywords
Embryonic stem cells; Pluripotency; Pluripotent stem cells; Reprogramming
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Funding
- Moxie Foundation
- Leona M. and Harry B. Helmsley Charitable Trust [2012-PG-MED002]
- G. Harold and Leila Y. Mathers Charitable Foundation
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Mammalian pluripotency is the ability to give rise to all somatic cells as well as the germ cells of an adult mammal. It is a unique feature of embryonic epiblast cells, existing only transiently, as cells pass through early developmental stages. By contrast, pluripotency can be captured and stabilized indefinitely in cell culture and can also be reactivated in differentiated cells via nuclear reprogramming. Pluripotent stem cells (PSCs) are the in vitro carriers of pluripotency and they can inhabit discrete pluripotent states depending on the stage at which they were derived and their culture conditions. Here, and in the accompanying poster, we provide a summary of mammalian pluripotency both in vivo and in vitro, and highlight recent and future applications of PSCs for basic and translational research.
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