4.5 Article

Impact of the COVID-19 outbreak and the serum prevalence of SARS-CoV-2 antibodies in patients with inflammatory bowel disease treated with biologic drugs

Journal

DIGESTIVE AND LIVER DISEASE
Volume 53, Issue 3, Pages 277-282

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2020.12.120

Keywords

Biologic therapy; IBD; SARS-CoV-2

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The study found that treatment with biologic drugs does not increase the risk of SARS-CoV-2 infection in patients with inflammatory bowel disease. The majority of patients did not get infected with the virus, and only a small number experienced mild symptoms, with very few requiring hospitalization.
Background: Patients receiving biologic therapies are at risk for viral infections. This study investigated the impact of the SARS-CoV-2 infection and the serum prevalence of SARS-CoV-2 antibodies in patients with inflammatory bowel disease (IBD) treated with biologic drugs. Methods: Information on demography, co-morbidities, clinical data regarding IBD, symptoms suggestive of the SARS-CoV-2 infection, close contacts with SARS-CoV-2 positive patients, hospitalization, and therapies administered for COVID-19 was collected for all patients who were being treated with biologic drugs. All patients underwent SARS-CoV-2 antibody testing. Results: Two hundred and fifty-nine patients (27 children) with a mean age of 42.2 +/- 16.7 years (range 9 - 88) and a mean duration of disease of 13.4 +/- 10 years (range 0.2 - 49) were enrolled. One hundred four patients (40.2%) had ulcerative colitis, and 155 (59.8%) had Crohn's disease. About the therapy: 62 patients were receiving infliximab, 89 adalimumab, 20 golimumab, 57 vedolizumab, 27 ustekinumab, 1 thalidomide, and 3 an experimental compound. The mean Charlson Comorbidity Index was 2. Thirty-two patients (12.3%) reported respiratory symptoms, and 2 of them were hospitalized (0.77%). Two patients resulted positive for IgG against SARS-CoV-2 (0.77%). Conclusions: In patients with IBD, treatment with biologic drug does not represent a risk factor for the SARS-CoV-2 infection. (C) 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

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