4.5 Article

Effect of water exchange method on adenoma miss rate of patients undergoing selective polypectomy: A randomized controlled trial

Journal

DIGESTIVE AND LIVER DISEASE
Volume 53, Issue 5, Pages 625-630

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2020.11.012

Keywords

Adenoma miss rate; Water exchange colonoscopy; Polypectomy; Air insufflated colonoscopy

Funding

  1. National Natural Science Foundation of China [81970557]
  2. Shaanxi Province Key RD Program [2020SF-223]

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This study compared the impact of water exchange and standard air insufflation colonoscopy on adenoma miss rate through a randomized control trial, and it remains uncertain which method can better increase the detection rate of missed adenomas.
Background: Adenomas may be missed in up to 40% of screening colonoscopies. Although the water exchange (WE) method can improve ADR, as shown in several RCTs, it remains uncertain whether it can increase the detection of missing adenomas compared with standard air-insufflated (AI) colonoscopy. Methods: Patients aged 18?80 years who underwent selective polypectomy were randomly allocated to the WE or AI group. The primary endpoint was the adenoma miss rate (AMR), defined as the number of patients with one or more additional adenomas during the polypectomy procedure divided by the total number of patients in each group.

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