Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 37, Issue 7, Pages -Publisher
WILEY
DOI: 10.1002/dmrr.3425
Keywords
frequent sampled intravenous glucose tolerance test; Korean; magnetic resonance spectroscopy; oral glucose tolerance test; pancreas
Categories
Funding
- Korean Diabetes Association [2016S-3]
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The study aimed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity, as well as glucose tolerance, in Korean adults. Results showed that as glucose tolerance deteriorated, PFC increased, and parameters related to insulin secretion decreased. The study found that PFC was higher in participants diagnosed with diabetes compared to those with normal glucose tolerance, and there was a significant negative correlation between PFC and indices reflecting beta cell function.
Aims This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. Materials A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as having diabetes but with less than 10 years of disease duration and no medication history were included. They were stratified according to the results of the oral glucose tolerance test (OGTT): normal glucose tolerance, prediabetes, and diabetes. Methods All participants underwent the proton magnetic resonance spectroscopy (H-1-MRS) to assess PFC. Insulin sensitivity and beta-cell function were measured by the frequently sampled intravenous glucose tolerance tests (FSIVGTT) and OGTT-derived indices. Results As glucose tolerance deteriorated, parameters such as Stumvoll index, oral glucose insulin sensitivity index, homeostatic model assessment (HOMA)-beta, insulinogenic index and oral disposition index from the OGTT, and acute insulin response to glucose (AIR) and disposition index (DI) from the FSIVGTT were decreased. PFC increased with deterioration in glucose tolerance (NGT: 12.0%, prediabetes: 23.7%, and diabetes: 31.9%). Correlation analysis indicated that glucose levels at 60 and 120 min during the OGTT were positively correlated with PFC. Also, there was a significant negative correlation between PFC and DI as well as AIR derived from the FSIVGTT. Conclusions PFC evaluated by H-1-MRS in Korean adults was higher in those diagnosed with diabetes than those with normal glucose tolerance status. PFC also showed a significant negative correlation with indices reflecting beta cell function.
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