Journal
DEVELOPMENTAL CELL
Volume 56, Issue 2, Pages 192-201Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2020.11.003
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Funding
- European Research Council (ERC Synergy Grant) [855158]
- Croatian Science Foundation (HRZZ) [IP-2019-045967, PZS-2019-02-7653]
- QuantiXLie Center of Excellence - Croatian Government
- European Union through the European Regional Development FundThe Competitiveness and Cohesion Operational Programme [KK.01.1.1.01.0004]
- ERC [647077]
- European Research Council (ERC) [855158, 647077] Funding Source: European Research Council (ERC)
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This Perspective discusses the advances in understanding spindle mechanics, with a focus on microtubule forces that control chromosome movements. Recent data and theoretical modeling have led to novel ideas and significant revisions of basic concepts in the field.
The mitotic spindle is a microtubule-based assembly that separates the chromosomes during cell division. As the spindle is basically a mechanical micro machine, the understanding of its functioning is constantly motivating the development of experimental approaches based on mechanical perturbations, which are complementary to and work together with the classical genetics and biochemistry methods. Recent data emerging from these approaches in combination with theoretical modeling led to novel ideas and significant revisions of the basic concepts in the field. In this Perspective, we discuss the advances in the understanding of spindle mechanics, focusing on microtubule forces that control chromosome movements.
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