Journal
DEVELOPMENTAL BIOLOGY
Volume 469, Issue -, Pages 26-36Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2020.09.009
Keywords
Kinesin; Microtubule; Embryo; Development; Cilia
Categories
Funding
- Provost Graduate Excellence Fellowship from the Institute of Cell and Molecular Biology, University of Texas at Austin
- NIAMS [R01AR072009]
- NICHD [R01HD085901]
- NHLBI [R01HL117164]
Ask authors/readers for more resources
This review highlights the specific developmental roles of kinesins, linking them to cellular functions reported in vitro, and points out the remaining gaps in our understanding of how this important family of proteins contributes to animal development and morphogenesis.
Kinesins are microtubule-based motor proteins that are well known for their key roles in cell biological processes ranging from cell division, to intracellular transport of mRNAs, proteins, vesicles, and organelles, and microtubule disassembly. Interestingly, many of the-45 distinct kinesin genes in vertebrate genomes have also been associated with specific phenotypes in embryonic development. In this review, we highlight the specific developmental roles of kinesins, link these to cellular roles reported in vitro, and highlight remaining gaps in our understanding of how this large and important family of proteins contributes to the development and morphogenesis of animals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available