Journal
DEVELOPMENT
Volume 148, Issue 2, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.193458
Keywords
Alveolar regeneration; Intermediate cell state; Niche; Stem cells
Categories
Funding
- National Key Research and Development Program of China [2020YFA0707400]
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This review discusses advances in understanding mammalian alveolar epithelial stem cell subpopulations and insights into the regeneration-specific cell status of alveolar epithelial stem cells, as well as how these advances can impact our understanding of post-injury lung repair processes and lung diseases.
The lungs are constantly exposed to the external environment and are therefore vulnerable to insults that can cause infection and injury. Maintaining the integrity and barrier function of the lung epithelium requires complex interactions of multiple cell lineages. Elucidating the cellular players and their regulation mechanisms provides fundamental information to deepen understanding about the responses and contributions of lung stem cells. This Review focuses on advances in our understanding of mammalian alveolar epithelial stem cell subpopulations and discusses insights about the regeneration-specific cell status of alveolar epithelial stem cells. We also consider how these advances can inform our understanding of post-injury lung repair processes and lung diseases.
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