Journal
CYTOSKELETON
Volume 77, Issue 12, Pages 558-578Publisher
WILEY
DOI: 10.1002/cm.21649
Keywords
centriole; centromere; centrosome; kinase; kinetochore; microtubules; mitotic spindle
Categories
Funding
- Division of Graduate Education [DGE-1650604]
- Division of Molecular and Cellular Biosciences [MCB1912837]
- National Institute of General Medical Sciences [GM007185, R01GM117475]
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The assembly of the bipolar mitotic spindle requires the careful orchestration of a myriad of enzyme activities like protein posttranslational modifications. Among these, phosphorylation has arisen as the principle mode for spatially and temporally activating the proteins involved in early mitotic spindle assembly processes. Here, we review key kinases, phosphatases, and phosphorylation events that regulate critical aspects of these processes. We highlight key phosphorylation substrates that are important for ensuring the fidelity of centriole duplication, centrosome maturation, and the establishment of the bipolar spindle. We also highlight techniques used to understand kinase-substrate relationships and to study phosphorylation events. We conclude with perspectives on the field of posttranslational modifications in early mitotic spindle assembly.
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