Journal
CYTOMETRY PART A
Volume 99, Issue 3, Pages 231-242Publisher
WILEY
DOI: 10.1002/cyto.a.24269
Keywords
dendritic cells; monocytes; professional antigen‐ presenting cells; mononuclear phagocyte system; high‐ dimensional flow cytometry; phenotyping; human immunology
Categories
Funding
- Intramural research program of the Vaccine Research Center, NIAID, NIH
- American Association of Immunologists
Ask authors/readers for more resources
Professional antigen-presenting cells (APCs), including dendritic cells (DCs) and monocytes, play vital roles in inducing and guiding adaptive T-cell responses. Recent advancements in single-cell analysis have improved our understanding of APC subset heterogeneity, with novel phenotyping markers helping to accurately resolve functional diversity. This report provides a concise overview of traditional and recently described markers for characterizing DCs and monocytes in the human system.
Professional antigen-presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T-cell responses. Recent technological developments in single-cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue-specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine-grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report, we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available