Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 21, Issue 6, Pages 462-506Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026621999201214232018
Keywords
1,2,3-triazole; Hybrid compounds; Fungal growth inhibition; Pathogenic fungi; Pharmacomodulation; Molecular modeling
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Funding
- Deanship of Scientific Research of King Faisal University [1811019]
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The study highlights the recent advances in the application of 1,2,3-triazole and its hybrids containing diverse bioactive heterocycles in the field of medicinal chemistry, especially their potential in antifungal activities, making significant progress in researching infectious fungal species.
1,2,3-Triazole, a five-membered heterocyclic nucleus, is widely recognized as a key chromophore of great value in medicinal chemistry for delivering compounds possessing innumerable biological activities, including antimicrobial, antitubercular, antidiabetic, antiviral, antitumor, antioxidants, and anti-inflammatory activities. Mainly, in the past years, diverse conjugates carrying this biologically valuable core have been reported due to their attractive fungicidal potential and potent effects on various infective targets. Hence, hybridization of 1,2,3-triazole with other antimicrobial pharmacophores appears to be a judicious strategy to develop new effective anti-fungal candidates to combat the emergence of drug-sensitive and drug-resistant infectious diseases. Thus, the current review highlights the recent advances of this promising category of 1,2,3-triazole-containing hybrids incorporating diverse varieties of bioactive heterocycles such as conozole, coumarin, imidazole, benzimidazole, pyrazole, indole, oxindole, chromene, pyrane, quinazoline, chalcone, isoflavone, carbohydrates, and amides. It underlies their inhibition behavior against a wide array of infectious fungal species during 2015-2020.
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