Journal
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 56, Issue 1, Pages 109-124Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2020.1869175
Keywords
Ribonucleotide incorporation; DNA replication; DNA repair; genome stability; genome-wide sequencing
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Funding
- Division of Intramural Research of the NIH, NIEHS [Z01 ES065070]
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Ribonucleotides are the most abundant non-canonical nucleotides in the genome, with significant influence on genome biology. Recent progress has been made in understanding their genomic presence, incorporation characteristics, and usefulness as biomarkers for polymerase enzymology. The discussion also covers ribonucleotide processing, genetic consequences of unrepaired ribonucleotides in DNA, and evidence supporting their transient presence in the nuclear genome.
Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their vast presence and influence over genome biology is becoming increasingly appreciated. Here we review the recent progress made in understanding their genomic presence, incorporation characteristics and usefulness as biomarkers for polymerase enzymology. We also discuss ribonucleotide processing, the genetic consequences of unrepaired ribonucleotides in DNA and evidence supporting the significance of their transient presence in the nuclear genome.
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