Intrinsic connectivity of anterior temporal lobe relates to individual differences in semantic retrieval for landmarks

Contemporary neuroscientific accounts suggest that ventral anterior temporal lobe (ATL) acts as a bilateral heteromodal semantic hub, which is particularly critical for the specific-level knowledge needed to recognise unique entities, such as familiar landmarks and faces. There may also be graded functional differences between left and right ATL, relating to effects of modality (linguistic versus non-linguistic) and category (e.g., knowledge of people and places). Individual differences in intrinsic connectivity from left and right ATL might be associated with variation in semantic categorisation performance across these categories and modalities. We recorded resting-state fMRI in 74 individuals and, in a separate session, examined semantic categorisation. People with greater connectivity between left and right ATL were more efficient at categorising landmarks (e.g., Eiffel Tower), especially when these were presented visually. In addition, participants who showed stronger con- nectivity from right than left ATL to medial occipital cortex showed more efficient semantic categorisation of landmarks regardless of modality of presentation. These results can be interpreted in terms of graded differences in the patterns of connectivity across left and right ATL, which give rise to a bilateral yet partially segregated semantic 'hub'. More specifically, right ATL connectivity supports the efficient semantic categorisation of landmarks. (C) 2020 Elsevier Ltd. All rights reserved.

Automated summary

Contemporary neuroscientific research suggests that the ventral anterior temporal lobe serves as a bilateral semantic hub critical for recognizing unique entities like landmarks and faces. There are graded functional differences between the left and right ATL, related to language versus non-language modalities and categories like people and places. Individual differences in intrinsic connectivity between the left and right ATL may affect semantic categorization performance across different categories and modalities.