Journal
CONTRACEPTION
Volume 103, Issue 3, Pages 171-177Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.contraception.2020.11.014
Keywords
Abortion; Dilapan; Dilation and evacuation; Laminaria; Osmotic dilator; Pain
Categories
Funding
- Society of Family Planning Research Fund [SFPRFSS18-04]
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This study compared pain levels and medication needs after placement of laminaria vs Dilapan-S, and after dilation and evacuation (D&E). The results showed that more participants reported higher levels of pain following dilator placement than D&E. Overall, the majority of patients will use a small amount of narcotics during their abortion procedure.
Objectives: To compare pain levels and medication needs after placement of laminaria vs Dilapan-S, and after dilation and evacuation (D&E). Study Design: We conducted a single-blinded randomized control trial of patients undergoing D&E at 15 0/7 to 23 6/7 weeks gestation, randomizing to cervical preparation with laminaria or Dilapan-S. We compared pain levels and medication usage following dilator placement (5 minutes; 2, 4, and 8 hours; the following morning) and D&E (1, 4, 24, and 48 hours). Our primary outcome was median change from baseline pain, and secondary outcomes included maximum pain timing and overall narcotic use. We compared baseline characteristics, median pain increases and quantities of narcotics used. Results: We analyzed 67 participants with laminaria (n = 34) and Dilapan-S (n = 33). More Dilapan-S users had a prior vaginal delivery (n = 20, 60.6%) than laminaria users (n = 11, 32.4%), p = 0.02. Maximum median pain was not statistically different (Laminaria: +3.5 (interquartile range [IQR] +0.5, +6.5); Dilapan-S: +3 (IQR +1, +5); p = 0.42. Thirty-seven (63.8%) participants reported higher levels of pain following dilator placement than D&E. Overall, 26 (42.6%) participants used narcotics during their abortion episode, with no difference in median number of tablets between laminaria (2, range 1-8) and Dilapan-S (4.5, range 1-15) participants (p = 0.34). Conclusions: Median pain increase did not differ in participants receiving laminaria or Dilapan-S for cervical preparation prior to D&E. The majority of patients will use a small amount of narcotics if available. (C) 2020 Elsevier Inc. All rights reserved.
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