Pulmonary Vascular Disease as a Systemic and Multisystem Disease

? Chronic heart failure syndrome is responsible for many of the common manifestations of pulmonary arterial hypertension (PAH), including activation of the sympathetic nervous system and reninangiotensin-aldosterone system. ? PAH is associated with changes in skeletal and respiratory muscle functions. There is evidence to support exercise training in reversing, to some extent, peripheral muscle dysfunction.

Automated summary

Chronic heart failure syndrome is linked to pulmonary arterial hypertension and can lead to activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system. PAH is also associated with changes in skeletal and respiratory muscle functions, but exercise training can help reverse peripheral muscle dysfunction to some extent.