Journal
CLINICAL TRANSPLANTATION
Volume 35, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/ctr.14140
Keywords
chronic lung allograft dysfunction; coronavirus infections; inhaled ribavirin; nasal corticosteroids
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This study found a significant burden of CARV infections during the first year after lung transplantation, with the use of nasal corticosteroids potentially increasing the risk of infection. However, CARV infections did not impact lung function or CLAD-free survival at 3 years.
Background The current study describes the spectrum of community-acquired respiratory infections (CARV) during the first year after lung transplantation (LT). Additionally, we elucidate variables associated with CARV, management strategies utilized, and impact on early and late outcomes. Methods This was a retrospective study among patients transplanted between 2012 and 2015 (n = 255, mean age 55.6 +/- 13.5 years, M: F 152:103). The diagnosis of CARV was based on the multiplex PCR on nasopharyngeal swab samples. Baseline characteristics, post-transplant variables, and outcomes were compared among patients with and without CARV. Results Eighty CARV infections developed among a quarter of the study group (n = 62, 24.3%). Rhinovirus/enterovirus was the most commonly isolated CARV (n = 24) followed by coronavirus (n = 17) and RSV (n = 9). A significant proportion of episodes (43.8%) required hospitalization. The use of nasal corticosteroids and left single LT was independently associated with an increased risk of CARV. CARV infections did not impact the lung functions during the first year or the CLAD-free survival at 3 years. Conclusions There is a significant burden of CARV infections during the first year after LT. The use of nasal corticosteroids may increase the risk of CARV infection. CARV infections did not impact outcomes.
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