Journal
CLINICAL INFECTIOUS DISEASES
Volume 73, Issue 11, Pages E4472-E4474Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1909
Keywords
Pseudomonas aeruginosa; cefiderocol; antibiotic resistance
Categories
Funding
- National Institutes of Health/National Institute of Allergy and Infectious Diseases NIH/NIAID [R01 AI134637, R01 AI148342, K01AI148593-01, K24 AI121296, K08 AI135093]
- UTHealth Presidential Award
- University of Texas System STARS Award
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A study reported the emergence of non-susceptibility to cefiderocol in a subpopulation of Pseudomonas aeruginosa recovered from a patient without prior exposure to the antibiotic. Whole genome sequencing revealed mutations in major iron transport pathways linked to cefiderocol uptake, highlighting the importance of susceptibility testing before therapy with siderophore cephalosporins.
We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.
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