Journal
CLINICAL INFECTIOUS DISEASES
Volume 73, Issue 4, Pages 726-729Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab045
Keywords
adults; hospitalization; influenza; vaccine effectiveness; waning
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The effectiveness of influenza vaccine decreases with time since vaccination, with an absolute decline of about 8%-9% per month postvaccination.
We observed decreased effectiveness of influenza vaccine with increasing time since vaccination for prevention of influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B/Yamagata-associated hospitalizations among adults. Maximum vaccine effectiveness (VE) was observed shortly after vaccination, followed by an absolute decline in VE of about 8%-9% per month postvaccination.
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