The circadian clock and inflammation: A new insight

The circadian clock is a complex cellular mechanism that controls a series of physiological processes, including inflammation. It can directly interact physically with the components of the key inflammatory pathway. Similarly, inflammation can also lead to circadian rhythm disorders, which may further amplify the inflammatory response and aggravate tissue damage. This review offers a structured overview that focusses on the core proteins of the circadian clock and their interactions with inflammatory players, and provides a potential mechanism for the pathological rhythms observed under inflammatory conditions.

Automated summary

The circadian clock influences physiological processes, including inflammation, and can physically interact with key inflammatory pathways. Inflammation, in turn, can disrupt the circadian rhythm, leading to exacerbated inflammatory responses and tissue damage. This review focuses on the interactions between core circadian clock proteins and inflammatory factors, providing insight into the potential mechanisms behind pathological rhythms observed in inflammatory conditions.