Oxidative dual C-H sulfenylation: A strategy for the synthesis of bis (imidazo[1,2-a]pyridin-3-yl)sulfanes under metal-free conditions using sulfur powder

An efficient approach to sulfur-bridged imidazopyridines has been developed under metal-free conditions using inexpensive sulfur powder as the sulfur source. Most appealingly, the reaction can proceed smoothly without addition of any additives, ultimately decreasing the production of chemical waste. The inexpensive and green method should provide a useful strategy for constructing a library of novel and biological interesting heteroaromatic sulfides. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

An efficient method for synthesizing sulfur-bridged imidazopyridines using inexpensive sulfur powder as the sulfur source has been developed under metal-free conditions. The reaction proceeds smoothly without the need for any additives, reducing the production of chemical waste. This cost-effective and green approach offers a useful strategy for constructing a library of novel and biologically interesting heteroaromatic sulfides.