Journal
CHINESE CHEMICAL LETTERS
Volume 32, Issue 5, Pages 1705-1708Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.12.046
Keywords
C-S bond; Metal-free; Sulfur powder; Disulfides; Heterocycle
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Funding
- National Natural Science Foundation of China [21302110]
- Natural Science Foundation of Shandong Province [ZR2016JL012]
- Scientific Research Foundation of Qingdao University of Science and Technology
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An efficient method for synthesizing sulfur-bridged imidazopyridines using inexpensive sulfur powder as the sulfur source has been developed under metal-free conditions. The reaction proceeds smoothly without the need for any additives, reducing the production of chemical waste. This cost-effective and green approach offers a useful strategy for constructing a library of novel and biologically interesting heteroaromatic sulfides.
An efficient approach to sulfur-bridged imidazopyridines has been developed under metal-free conditions using inexpensive sulfur powder as the sulfur source. Most appealingly, the reaction can proceed smoothly without addition of any additives, ultimately decreasing the production of chemical waste. The inexpensive and green method should provide a useful strategy for constructing a library of novel and biological interesting heteroaromatic sulfides. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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