Journal
CHINESE CHEMICAL LETTERS
Volume 32, Issue 1, Pages 99-101Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.11.025
Keywords
Corneal neovascularization; Phototherapy; Nanotechnology; R-nanolCG; Photoacoustic imaging
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Funding
- National Key R&D Program of China [2018YFA0107301, 2018YFA0107304]
- National Natural Science Foundation of China (NSFC) [81770894, 81901876, 81470602, 81330022]
- Fundamental Research Funds for the Central Universities [20720190088, 20720200019]
- Medical and Health Key Project of Xiamen [3502Z20191106]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
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The use of phototherapy combined with functional nanoparticles featuring photoacoustic imaging contrast properties can achieve accurate and safe inhibition of CNV, showing promise in clinical application.
Corneal neovascularization (CNV) can induce severe visual impairment and even blindness. Current treatments have limited efficacy and some undesirable side effects. Phototherapy (PT) is a modern medical technique in CNV treatment and worth further improvement. Nanotechnology has various advantages and nanoparticle-mediated drug delivery also contributes to CNV elimination. Phototherapy combined with functional nanoparticles featuring photoacoustic imaging contrast properties can accomplish accurate and safe inhibition of CNV, thus is promising in clinical application. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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