Related references
Note: Only part of the references are listed.Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders
Meng Cheng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
How reliable are in vitro IC50 values? Values vary with cytotoxicity assays in human glioblastoma cells
Elisabetta Damiani et al.
TOXICOLOGY LETTERS (2019)
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma
Christopher R. M. Asquith et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S
Qiannan Li et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators as a Therapy for Glioblastoma
Muhammad Nadeem Abbas et al.
CELLS (2019)
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S)
Jiayi Shen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma
Christopher R. M. Asquith et al.
CHEMMEDCHEM (2019)
A novel scaffold for EGFR inhibition: Introducting N-(3-(3-phenylureido)quinoxalin-6-yl) acrylamide derivatives
Daniel Nascimento do Amaral et al.
SCIENTIFIC REPORTS (2019)
Fabrication and characterization of solid lipid nano-formulation of astraxanthin against DMBA-induced breast cancer via Nrf-2-Keap1 and NF-kB and mTOR/Maf-1/PTEN pathway
Tao Sun et al.
DRUG DELIVERY (2019)
MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer
Ying Zhang et al.
MOLECULAR CANCER (2018)
Quinazoline clubbed 1,3,5-triazine derivatives as VEGFR2 kinase inhibitors: design, synthesis, docking, in vitro cytotoxicity and in ovo antiangiogenic activity
Prateek Pathak et al.
INFLAMMOPHARMACOLOGY (2018)
Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D-Aromatic-Boron-Rich-Cluster into the 4-Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment
Marcos Couto et al.
CHEMISTRY-A EUROPEAN JOURNAL (2018)
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
Daniel P. Bondeson et al.
CELL CHEMICAL BIOLOGY (2018)
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
George M. Burslem et al.
CELL CHEMICAL BIOLOGY (2018)
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode
Aoli Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Michiru Nishita et al.
SCIENTIFIC REPORTS (2017)
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Philipp M. Cromm et al.
CELL CHEMICAL BIOLOGY (2017)
Discovery of EGF Receptor Inhibitors That Are Selective for the d746-750/T790M/C797S Mutant through Structure-Based de Novo Design
Hwangseo Park et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy
Philipp Ottis et al.
ACS CHEMICAL BIOLOGY (2017)
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase
Emily J. Hanan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs
Chin Siang Kue et al.
EXPERIMENTAL ANIMALS (2015)
The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities
Samuel Genheden et al.
EXPERT OPINION ON DRUG DISCOVERY (2015)
Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach
Julian Engel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Catalytic in vivo protein knockdown by small-molecule PROTACs
Daniel P. Bondeson et al.
NATURE CHEMICAL BIOLOGY (2015)
AtomicChargeCalculator: interactive web-based calculation of atomic charges in large biomolecular complexes and drug-like molecules
Crina-Maria Ionescu et al.
JOURNAL OF CHEMINFORMATICS (2015)
Hybrid 4-Aminoquinoline-1,3,5-triazine Derivatives: Design, Synthesis, Characterization, and Antibacterial Evaluation
P. Pathak et al.
JOURNAL OF HETEROCYCLIC CHEMISTRY (2015)
The in vivo evaluation of anti-angiogenic effects of Hypericum essential oils using the chorioallantoic membrane assay
Hulya Tuba Kiyan et al.
PHARMACEUTICAL BIOLOGY (2014)
Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats
Ashraf Y. Nasr
TOXICOLOGY REPORTS (2014)
6-Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib-Sensitive and -Resistant Tumor Cell Lines
Mostafa M. Hamed et al.
CHEMMEDCHEM (2013)
Synthesis, Antitumor Evaluation and Docking Study of Novel 4-Anilinoquinazoline Derivatives as Potential Epidermal Growth Factor Receptor (EGFR) Inhibitors
Guo-Wu Rao et al.
CHEMMEDCHEM (2013)
Quinazoline-based multi-tyrosine kinase inhibitors: Synthesis, modeling, antitumor and antiangiogenic properties
Maria Teresa Conconi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
Daniel R. Roe et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)
Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
Jin H. Park et al.
BIOCHEMICAL JOURNAL (2012)
Free Energy Calculations by the Molecular Mechanics Poisson-Boltzmann Surface Area Method
Nadine Homeyer et al.
MOLECULAR INFORMATICS (2012)
A General Framework for Inhibitor Resistance in Protein Kinases
Deborah Balzano et al.
CHEMISTRY & BIOLOGY (2011)
Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations
Tingjun Hou et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Through the Gatekeeper Door: Exploiting the Active Kinase Conformation
Fabio Zuccotto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Antitumor actions of imidazolyl-(4-oxoquinazolin-3(4H)-yl)-acetamides against Ehrlich Ascites Carcinoma
Nulgumnalli Manjunathaiah Raghavendra et al.
ARCHIVES OF PHARMACAL RESEARCH (2009)
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
Garrett M. Morris et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.)
L. Krenn et al.
PHYTOMEDICINE (2009)
EGFR tyrosine kinase inhibitors in lung cancer: An evolving story
Lecia V. Sequist et al.
ANNUAL REVIEW OF MEDICINE (2008)
Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase
Khaled Abouzid et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin
Dhrubajyoti Chakravarti et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2008)
Cellular responses to EGFR inhibitors and their relevance to cancer therapy
Pinaki R. Dutta et al.
CANCER LETTERS (2007)
Epidermal growth factor receptor mutations in lung cancer
Sreenath V. Sharma et al.
NATURE REVIEWS CANCER (2007)
Lapatinib in the treatment of breast cancer
Gerald M. Higa et al.
EXPERT REVIEW OF ANTICANCER THERAPY (2007)
Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs
Sarah T. Al-Rashood et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Rational design of inhibitors that bind to inactive kinase conformations
Y Liu et al.
NATURE CHEMICAL BIOLOGY (2006)
Tyrosine kinases as targets for cancer therapy
DS Krause et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
ER Wood et al.
CANCER RESEARCH (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RaIGDS complexes
H Gohlke et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Receptor tyrosine kinase signalling as a target for cancer intervention strategies
E Zwick et al.
ENDOCRINE-RELATED CANCER (2001)
Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones
Y Xia et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents
MJ Morin
ONCOGENE (2000)
Signaling networks: The origins of cellular multitasking
JD Jordan et al.
CELL (2000)