Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 13, Pages 4332-4335Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202005401
Keywords
nucleic acids; nucleobases; peptide nucleic acids; RNA recognition; triple helix
Categories
Funding
- U.S. National Science Foundation [CHE-1708699, CHE-1708671]
- Latvian Institute of Organic Synthesis internal research fund [IG-2019-04]
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Peptide nucleic acids (PNA) with extended isoorotamides containing nucleobases (I-o) were designed to bind A-U base pairs in double-stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments showed improved affinity for A-U using the Io scaffold in PNA, with PNAs having four sequential Io extended nucleobases maintaining high binding affinity.
Peptide nucleic acids (PNA) with extended isoorotamide containing nucleobases (I-o) were designed for binding A-U base pairs in double-stranded RNA. Isothermal titration calorimetry and UV thermal melting experiments revealed improved affinity for A-U using the Io scaffold in PNA. PNAs having four sequential Io extended nucleobases maintained high binding affinity.
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