Journal
CHEMISTRY LETTERS
Volume 50, Issue 1, Pages 187-190Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.200633
Keywords
Amphiphilic dendrimer; Lipid membrane; Hydration state
Categories
Funding
- JSPS Research Fellowship from the Japan Society for the Promotion of Science (JSPS) [18J22897, 26249116, 18H02005]
- KEIRIN RACE
- NICA Fellows program
- Grants-in-Aid for Scientific Research [18J22897, 18H02005] Funding Source: KAKEN
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In this study, coassemblies of lipids and polyamidoamine amphiphilic dendrons (AD) were prepared using different generations and composition ratios of AD. It was found that the generation of AD significantly influenced the structure and hydration state of the coassemblies.
Coassembly of lipids and polyamidoamine amphiphilic dendrons (AD) is expected to provide desirable characteristics to drug delivery carriers. However, there have been few studies about structure and properties of these coassemblies. In this study, coassemblies (lipid-AD) were prepared by different generation and composition ratio of AD, and then the structure and their properties were characterized, especially fluidity and hydration state. In conclusion, generation of AD showed significant influence on coassembly structure and hydration state.
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