Recent Progress in Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-depolymerizing Natural Product

Aplyronine A, an antitumor marine macrolide, has a novel mode of action, inducing the protein-protein interaction between two major cytoskeletons, actin and tubulin. This review discusses recent progress in the design of artificial analogs including hybridization and structure-activity relationship studies of aplyronine A.

Automated summary

This review discusses recent progress in the design of artificial analogs of Aplyronine A, including hybridization and structure-activity relationship studies, to further understand its novel mode of action as an antitumor marine macrolide inducing protein-protein interaction between actin and tubulin.