Microwave-specific Enhancement of Nazarov Cyclization

A copper-catalyzed Nazarov cyclization was carried out under conventional heating conditions and microwave conditions. Under strictly temperature-controlled conditions, the use of microwave irradiation improved the chemical yields. Consequently, the kinetic rate of the microwave irradiation was 5.8 times higher than that of the conventional heating conditions. These observations suggested that the microwave specific effects enhanced the efficiency of the Nazarov reaction.

Automated summary

The copper-catalyzed Nazarov cyclization was carried out under both conventional heating and microwave conditions. The use of microwave irradiation under strictly temperature-controlled conditions improved the chemical yields and increased the kinetic rate by 5.8 times compared to conventional heating conditions, suggesting that microwave-specific effects enhanced the efficiency of the Nazarov reaction.