4.5 Article

New Pyrano-4H-benzo[g]chromene-5,10-diones with Antiparasitic and Antioxidant Activities

Journal

CHEMISTRY & BIODIVERSITY
Volume 18, Issue 1, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000839

Keywords

lawsone; neglected tropical diseases; pyran; biological activity

Funding

  1. Projekt DEAL

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New pyranonaphthoquinone derivatives show varied activities against different parasites, indicating potential therapeutic value. Some derivatives exhibit antioxidant activities, suggesting potential for other biological activities.
New pyranonaphthoquinone derivatives were synthesized and investigated for their activity against Trypanosoma brucei, Leishmania major, and Toxoplasma gondii parasites. The pentafluorophenyl derivative was efficacious against T. brucei with single digit micromolar EC50 values and against T. gondii with even sub-micromolar values. The 3-chloro-4,5-dimethoxyphenyl derivative showed an activity against amastigotes of Leishmania major parasites comparable to that of amphotericin B. In addition, antioxidant activities were observed for the bromophenyl derivatives, and their redox behavior was studied by cyclovoltammetry. Anti-parasitic and antioxidative activities of the new naphthoquinone derivatives appear uncorrelated.

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