Journal
CHEMISTRY & BIODIVERSITY
Volume 18, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202000639
Keywords
arthpyrone L; Arthrinium; antiproliferation; osteosarcoma
Funding
- National Natural Science Foundation of China [31501104]
- Project of Shandong Province Higher Educational Youth Innovation Science and Technology Program [2019KJB021]
- Interdisciplinary Project of University of Jinan [XKY1635]
- Jinan Science & Technology Bureau Innovation Team Project [2018GXRC003]
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Fractionation of the ethanol extract of a marine fungus, Arthrinium sp., led to the isolation of a new pyridone alkaloid, which exhibited antiproliferative effects on various cancer cells and induced apoptosis and cell cycle arrest in MG63 cell lines. Mechanism studies showed that the growth inhibition was achieved through caspase-modulated apoptotic pathway activation and PI3K/Akt pathway inhibition.
Fractionation of the ethanol extract of a marine fungus, Arthrinium sp., afforded a new pyridone alkaloid (arthpyrone L (1)), the structure with absolute configuration of which was established by comprehensive spectroscopic analyses. In vitro cell viability assays revealed that compound 1 showed antiproliferative effects toward human A549 (lung), MG63, U2OS (bone), MCF-7 and MDA-MB-231 (breast) cancer cells. MG63 cell lines were chosen for further biological evaluations and presented apoptosis and cell cycle arrest (G0/G1 phase) upon treatment of 1. Subsequent mechanism studies demonstrated that the growth inhibition of 1 against MG63 cells was via activation of caspase-modulated apoptotic pathway and inhibition of PI3K/Akt pathway.
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