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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)
Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity
Hanneke G. M. Wittgen et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Regulation of ABCA1 functions by signaling pathways
Yuhua Liu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)
Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells
C. Fahrmayr et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays
Petra Krumpochova et al.
FASEB JOURNAL (2012)
Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysis
Yannick Bacq et al.
GASTROENTEROLOGY (2012)
The histidin-loop is essential for transport activity of human MDR3. A novel mutation of MDR3 in a patient with progressive familial intrahepatic cholestasis type 3
Tamar Dzagania et al.
GENE (2012)
A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
Simon Hohenester et al.
HEPATOLOGY (2012)
ABCMdb: A database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application
Gergely Gyimesi et al.
HUMAN MUTATION (2012)
Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice
Maite G. Fernandez-Barrena et al.
JOURNAL OF HEPATOLOGY (2012)
Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2
Emmanuel Gonzales et al.
JOURNAL OF HEPATOLOGY (2012)
Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans
Mi Sun Jin et al.
NATURE (2012)
ABCG2 null alleles define the Jr(a-) blood group phenotype
Teresa Zelinski et al.
NATURE GENETICS (2012)
X-ray structure of the Yersinia pestis heme transporter HmuUV
Jae-Sung Woo et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation
Michael Hohl et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases
Ryan D. Baldridge et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer
Faraz Quazi et al.
NATURE COMMUNICATIONS (2012)
Decreased extra-renal urate excretion is a common cause of hyperuricemia
Kimiyoshi Ichida et al.
NATURE COMMUNICATIONS (2012)
The bile salt export pump (BSEP) in health and disease
Ralf Kubitz et al.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2012)
Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial
Lucy C. Chappell et al.
BMJ-BRITISH MEDICAL JOURNAL (2012)
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Huan Yan et al.
ELIFE (2012)
Characterization of the Role of ABCG2 as a Bile Acid Transporter in Liver and Placenta
Alba G. Blazquez et al.
MOLECULAR PHARMACOLOGY (2012)
Imaging of Hepatobiliary Disorders Complicating Pregnancy
Matthew T. Heller et al.
AMERICAN JOURNAL OF ROENTGENOLOGY (2011)
Morphologic Findings in Progressive Familial Intrahepatic Cholestasis 2 (PFIC2): Correlation With Genetic and Immunohistochemical Studies
Kimberley Evason et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2011)
Living-Related Liver Transplantation for Siblings with Progressive Familial Intrahepatic Cholestasis 2, with Novel Genetic Findings
H. Shimizu et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2011)
ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions
Gergely Gyimesi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane
Laszlo Homolya et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
The ABCG family of membrane-associated transporters: you don't have to be big to be mighty
Ian D. Kerr et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Description of two new ABCB11 mutations responsible for type 2 benign recurrent intrahepatic cholestasis in a French-Canadian family
Yannick Beausejour et al.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2011)
FDA-approved drug labeling for the study of drug-induced liver injury
Minjun Chen et al.
DRUG DISCOVERY TODAY (2011)
Mammalian multidrug-resistance proteins (MRPs)
Andrew J. Slot et al.
ESSAYS IN BIOCHEMISTRY: ABC TRANSPORTERS (2011)
The controversial role of ABC transporters in clinical oncology
Akina Tamaki et al.
ESSAYS IN BIOCHEMISTRY: ABC TRANSPORTERS (2011)
Increased plasma plant sterol concentrations and a heterozygous amino acid exchange in ATP binding cassette transporter ABCG5: A case report
Sylvia Keller et al.
EUROPEAN JOURNAL OF MEDICAL GENETICS (2011)
Granulin-Epithelin Precursor and ATP-Dependent Binding Cassette (ABC)B5 Regulate Liver Cancer Cell Chemoresistance
Siu Tim Cheung et al.
GASTROENTEROLOGY (2011)
Sequences in the Nonconsensus Nucleotide-binding Domain of ABCG5/ABCG8 Required for Sterol Transport
Jin Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Interaction of bile salts with rat canalicular membrane vesicles: Evidence for bile salt resistant microdomains
Christelle Guyot et al.
JOURNAL OF HEPATOLOGY (2011)
Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma
Kishore Polireddy et al.
MOLECULAR ONCOLOGY (2011)
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT
Nien-Jen Hu et al.
NATURE (2011)
Heterologous Overexpression and Mutagenesis of the Human Bile Salt Export Pump (ABCB11) Using DREAM (Directed REcombination-Assisted Mutagenesis)
Jan Stindt et al.
PLOS ONE (2011)
Reaction chemistry ABC-style
Alan E. Senior
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Progressive Familial Intrahepatic Cholestasis (PFIC) Type 1, 2, and 3: A Review of the Liver Pathology Findings
Raffaella A. Morotti et al.
SEMINARS IN LIVER DISEASE (2011)
Cholestatic Liver Diseases from Child to Adult: The Diversity of MDR3 Disease
R. Kubitz et al.
ZEITSCHRIFT FUR GASTROENTEROLOGIE (2011)
Bile Acids Stimulate ATP Hydrolysis in the Purified Cholesterol Transporter ABCG5/G8
Brandy J. Harvey Johnson et al.
BIOCHEMISTRY (2010)
The mouse mutation thrombocytopenia and cardiomyopathy (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia
Thomas H. Chase et al.
BLOOD (2010)
Vectorial Transport of Nucleoside Analogs from the Apical to the Basolateral Membrane in Double-Transfected Cells Expressing the Human Concentrative Nucleoside Transporter hCNT3 and the Export Pump ABCC4
Maria Rius et al.
DRUG METABOLISM AND DISPOSITION (2010)
Role of the bile salt export pump, BSEP, in acquired forms of cholestasis
Bruno Stieger
DRUG METABOLISM REVIEWS (2010)
Regulation of hepatic ABCC transporters by xenobiotics and in disease states
Xinsheng Gu et al.
DRUG METABOLISM REVIEWS (2010)
Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served?
Robert Ernst et al.
FEBS JOURNAL (2010)
ATP8B1 and ABCB11 Analysis in 62 Children with Normal Gamma-Glutamyl Transferase Progressive Familial Intrahepatic Cholestasis (PFIC): Phenotypic Differences Between PFIC1 and PFIC2 and Natural History
Anne Davit-Spraul et al.
HEPATOLOGY (2010)
A Flippase-Independent Function of ATP8B1, the Protein Affected in Familial Intrahepatic Cholestasis Type 1, Is Required for Apical Protein Expression and Microvillus Formation in Polarized Epithelial Cells
Patricia M. Verhulst et al.
HEPATOLOGY (2010)
Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia
Jonathan Rios et al.
HUMAN MOLECULAR GENETICS (2010)
Current Therapy for Patients with Sitosterolemia-Effect of Ezetimibe on Plant Sterol Metabolism
Kazumi Tsubakio-Yamamoto et al.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2010)
Interaction of Extracellular Domain 2 of the Human Retina-specific ATP-binding Cassette Transporter (ABCA4) with All-trans-retinal
Esther E. Biswas-Fiss et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type 2
Giuseppe Maggiore et al.
JOURNAL OF HEPATOLOGY (2010)
DHPLC screening for mutations in progressive familial intrahepatic cholestasis patients
Rivka Shapiro et al.
JOURNAL OF HUMAN GENETICS (2010)
Clinical observations, molecular genetic analysis, and treatment of sitosterolemia in infants and children
Dau-Ming Niu et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2010)
ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis
Lily Jakulj et al.
JOURNAL OF LIPID RESEARCH (2010)
Analysis of Gene Mutations in Children With Cholestasis of Undefined Etiology
Ursula Matte et al.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2010)
ABCB11 gene mutations in Chinese children with progressive intrahepatic cholestasis and low γ glutamyltransferase
Li-Yan Liu et al.
LIVER INTERNATIONAL (2010)
Combined features of low phospholipid-associated cholelithiasis and progressive familial intrahepatic cholestasis 3
Raoul Poupon et al.
LIVER INTERNATIONAL (2010)
Recurrent Low Gamma-Glutamyl Transpeptidase Cholestasis Following Liver Transplantation for Bile Salt Export Pump (BSEP) Disease (Posttransplant Recurrent BSEP Disease)
Leah Siebold et al.
LIVER TRANSPLANTATION (2010)
Structure of a cation-bound multidrug and toxic compound extrusion transporter
Xiao He et al.
NATURE (2010)
Revitalizing membrane rafts: new tools and insights
Kai Simons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability
Richard H. Ho et al.
PHARMACOGENETICS AND GENOMICS (2010)
PDR-type ABC transporter mediates cellular uptake of the phytohormone abscisic acid
Joohyun Kang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains
Libusha Kelly et al.
PROTEIN SCIENCE (2010)
The Spectrum of Liver Diseases Related to ABCB4 Gene Mutations: Pathophysiology and Clinical Aspects
Anne Davit-Spraul et al.
SEMINARS IN LIVER DISEASE (2010)
Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1
Daniel A. P. Gutmann et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters
Simone Leuthold et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Molecular Mechanisms of Subcellular Localization of ABCG5 and ABCG8
Takashi Hirata et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2009)
Recent insights into the function and regulation of the bile salt export pump (ABCB11)
Bruno Stieger
CURRENT OPINION IN LIPIDOLOGY (2009)
Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors
Emese Kis et al.
DRUG METABOLISM AND DISPOSITION (2009)
Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population
Su-Ryang Kim et al.
DRUG METABOLISM AND PHARMACOKINETICS (2009)
Hepatobiliary ABC transporters: physiology, regulation and implications for disease
Johan W. Jonker et al.
FRONTIERS IN BIOSCIENCE (2009)
Burden of Digestive Diseases in the United States Part III: Liver, Biliary Tract, and Pancreas
James E. Everhart et al.
GASTROENTEROLOGY (2009)
Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy
P. H. Dixon et al.
GUT (2009)
ABC-Transporters Are Localized in Caveolin-1-Positive and Reggie-1-Negative and Reggie-2-Negative Microdomains of the Canalicular Membrane in Rat Hepatocytes
Manfred G. Ismair et al.
HEPATOLOGY (2009)
Missense Mutations and Single Nucleotide Polymorphisms in ABCB11 Impair Bile Salt Export Pump Processing and Function or Disrupt Pre-Messenger RNA Splicing
Jane A. Byrne et al.
HEPATOLOGY (2009)
Low Retinol Levels Differentially Modulate Bile Salt-Induced Expression of Human and Mouse Hepatic Bile Salt Transporters
Martijn O. Hoeke et al.
HEPATOLOGY (2009)
The Transporter Variome: the Missing Link Between Gene Variants and Bile Salt Transporter Function
Roman Muellenbach et al.
HEPATOLOGY (2009)
De Novo Bile Salt Transporter Antibodies as a Possible Cause of Recurrent Graft Failure After Liver Transplantation: a Novel Mechanism of Cholestasis
Verena Keitel et al.
HEPATOLOGY (2009)
Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4
Yuki Ikebuchi et al.
HEPATOLOGY RESEARCH (2009)
EASL Clinical Practice Guidelines: Management of cholestatic liver diseases
Ulrich Beuers et al.
JOURNAL OF HEPATOLOGY (2009)
Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation
Kohjiro Nagao et al.
JOURNAL OF LIPID RESEARCH (2009)
A novel role for ABCA1-generated large pre-β migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion
Soonkyu Chung et al.
JOURNAL OF LIPID RESEARCH (2009)
Analysis of DNA Methylation and Histone Modification Profiles of Liver-Specific Transporters
Satoki Imai et al.
MOLECULAR PHARMACOLOGY (2009)
Brief Report: Recurrence of Bile Salt Export Pump Deficiency after Liver Transplantation.
Paloma Jara et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Philippe Lefebvre et al.
PHYSIOLOGICAL REVIEWS (2009)
Progressive familial intrahepatic cholestasis
Anne Davit-Spraul et al.
ORPHANET JOURNAL OF RARE DISEASES (2009)
Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae
Eimear E. Kenny et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast
Xiaoming Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
Owen M. Woodward et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Opening of the ADP-bound active site in the ABC transporter ATPase dimer: Evidence for a constant contact, alternating sites model for the catalytic cycle
Peter M. Jones et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2009)
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
Stephen G. Aller et al.
SCIENCE (2009)
Novel ABCB11 mutations in a Thai infant with progressive familial intrahepatic cholestasis
Suporn Treepongkaruna et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2009)
Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells
Tatehiro Kagawa et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Multidrug transport by the ABC transporter Sav 1866 from Staphylococcus aureus
Saroj Velamakanni et al.
BIOCHEMISTRY (2008)
Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4)
Aina Westrheim Ravna et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease
K-K. Kuo et al.
BRITISH JOURNAL OF SURGERY (2008)
HDL, ABC transporters, and cholesterol efflux: Implications for the treatment of atherosclerosis
Alan R. Tall et al.
CELL METABOLISM (2008)
Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
A. F. Hofmann et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy
A. Floreani et al.
DIGESTIVE AND LIVER DISEASE (2008)
Severe bile salt export pump deficiency:: 82 different ABCB11 mutations in 109 families
Sandra S. Strautnieks et al.
GASTROENTEROLOGY (2008)
Degradation of the Bile Salt Export Pump at Endoplasmic Reticulum in Progressive Familial Intrahepatic Cholestasis Type II
Lin Wang et al.
HEPATOLOGY (2008)
The Membrane Protein ATPase Class I Type 813 Member 1 Signals Through Protein Kinase C Zeta To Activate the Farnesoid X Receptor
Tamara Frankenberg et al.
HEPATOLOGY (2008)
Diagnosis of BSEP/ABCB11 Mutations in Asian Patients with Cholestasis Using Denaturing High Performance Liquid Chromatography
Huey-Ling Chen et al.
JOURNAL OF PEDIATRICS (2008)
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
Abbas Dehghan et al.
LANCET (2008)
Identification of regions required for apical membrane localization of human multidrug resistance protein 2
Paul E. Bandler et al.
MOLECULAR PHARMACOLOGY (2008)
The ABC transporter AtABCB14 is a malate importer and modulates stomatal response to CO2
Miyoung Lee et al.
NATURE CELL BIOLOGY (2008)
Hepatic insulin resistance directly promotes formation of cholesterol gallstones
Sudha B. Biddinger et al.
NATURE MEDICINE (2008)
Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease
Iwona Rudkowska et al.
NUTRITION REVIEWS (2008)
The Role of FXR in Disorders of Bile Acid Homeostasis
Jyrki J. Eloranta et al.
PHYSIOLOGY (2008)
A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5
Robert Ernst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules
Frans G. M. Russel et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy
Silvia Sookoian et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Bile acid transporters in health and disease
A. Kosters et al.
XENOBIOTICA (2008)
Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)
Anne T. Nies et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)
Variability in human hepatic MRP4 expression: influence of cholestasis and genotype
U. Gradhand et al.
PHARMACOGENOMICS JOURNAL (2008)
Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases
Michael Trauner et al.
WIENER MEDIZINISCHE WOCHENSCHRIFT (2008)
Disruption of cAMP and prostaglandin E-2 transport by multidrug resistance protein 4 deficiency alters cAMP-Mediated signaling and nociceptive response
Z. Ping Lin et al.
MOLECULAR PHARMACOLOGY (2008)
Molecular characterization and structural implications of 25 new ABCB4 mutations in progressive familial intrahepatic cholestasis type 3 (PFIC3)
Dario Degiorgio et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2007)
Gradual improvement of liver function after administration of ursodeoxycholic acid in an infant with a novel ABCB11 gene mutation with phenotypic continuum between BRIC2 and PFIC2
Atsushi Takahashi et al.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2007)
Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases
Ping Lam et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine
Ho-Sook Kim et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2007)
The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux
Carlos Vrins et al.
FEBS LETTERS (2007)
Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro
Caroline Henrike Storch et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Bile acid transporters: Structure, function, regulation and pathophysiological implications
Waddah A. Alrefai et al.
PHARMACEUTICAL RESEARCH (2007)
Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF
Rikki N. Hvorup et al.
SCIENCE (2007)
Liver transplantation for progressive familial intrahepatic cholestasis: Clinical and histopathological findings, outcome and impact on growth
Sema Aydogdu et al.
PEDIATRIC TRANSPLANTATION (2007)
ATP binding cassette G8 T400K polymorphism may affect the risk of gallstone disease among Chinese males
Yong Wang et al.
CLINICA CHIMICA ACTA (2007)
Data-based mathematical Modeling of vectorial transport across double-transfected polarized cells
Kilian Bartholome et al.
DRUG METABOLISM AND DISPOSITION (2007)
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Stephan Buch et al.
NATURE GENETICS (2007)
Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy
Saskia W. C. Van Mil et al.
GASTROENTEROLOGY (2007)
Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters
Shizuko Tachibana et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2007)
Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function
Isabelle J. Letourneau et al.
DRUG METABOLISM AND DISPOSITION (2007)
Structure and mechanism of ABC transporter proteins
Kaspar Hollenstein et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)
Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4
Shin-ya Morita et al.
HEPATOLOGY (2007)
Cooperative interaction between hepatocyte nuclear factor 4α and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8
Koichi Sumi et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps
Hisamitsu Hayashi et al.
HEPATOLOGY (2007)
Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma
A. O. Scheimann et al.
JOURNAL OF PEDIATRICS (2007)
Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate
Ho Jung Shin et al.
HEPATOLOGY (2007)
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
Liam R. Brunham et al.
NATURE MEDICINE (2007)
ABCA1, from pathology to membrane function
Ana Zarubica et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
MDR3 (ABCB4) defects:: A paradigm for the genetics of adult cholestatic syndromes
Michael Trauner et al.
SEMINARS IN LIVER DISEASE (2007)
The bile salt export pump
Bruno Stieger et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
The apical conjugate efflux pump ABCC2 (MRP2)
Anne T. Nies et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols
Starr E. Hazard et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)
Ronald P. J. Oude Elferink et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited
Federica Basso et al.
JOURNAL OF LIPID RESEARCH (2007)
Organic anion transporting polypeptide 2B1 and breast cancer resistance protein interact in the transepithelial transport of steroid sulfates in human placenta
Markus Grube et al.
DRUG METABOLISM AND DISPOSITION (2007)
Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2-and MRP4/ABCC4-mediated methotrexate transport
Azza A. K. El-Sheikh et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump
Aki Sakurai et al.
EXPERT OPINION ON DRUG SAFETY (2007)
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
Andreas Geier et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
Emilie Jigorel et al.
DRUG METABOLISM AND DISPOSITION (2006)
Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations
Miki Hiasa et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Structure of a bacterial multidrug ABC transporter
Roger J. P. Dawson et al.
NATURE (2006)
The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice
Astrid Kosters et al.
JOURNAL OF LIPID RESEARCH (2006)
Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)
Thomas Lang et al.
DRUG METABOLISM AND DISPOSITION (2006)
LmrCD is a major multidrug resistance transporter in Lactococcus lactis
Jacek Lubelski et al.
MOLECULAR MICROBIOLOGY (2006)
Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency
A. S. Knisely et al.
HEPATOLOGY (2006)
Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy
Verena Keitel et al.
GASTROENTEROLOGY (2006)
A structural analysis of asymmetry required for catalytic activity of an ABC-ATPase domain dimer
Jelena Zaitseva et al.
EMBO JOURNAL (2006)
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport
Coen C. Paulusma et al.
HEPATOLOGY (2006)
Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
Yvonne Meier et al.
HEPATOLOGY (2006)
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Roger G. Deeley et al.
PHYSIOLOGICAL REVIEWS (2006)
A new ABCB11 mutation in two Italian children with familial intrahepatic cholestasis
Valerio Nobili et al.
JOURNAL OF GASTROENTEROLOGY (2006)
Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis
A Mennone et al.
HEPATOLOGY (2006)
Characterization of mice lacking the multidrug resistance protein Mrp2 (Abcc2)
XY Chu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides
N Zelcer et al.
JOURNAL OF HEPATOLOGY (2006)
The motor domains of ABC-transporters - What can structures tell us?
C Oswald et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)
Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep
S Mita et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor
Y Honjo et al.
JOURNAL OF ENDOCRINOLOGY (2006)
A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans
B Pandit et al.
BMC MEDICAL GENETICS (2006)
Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8
DW Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Molecular insights into the mechanism of ATP-hydrolysis by the NBD of the ABC-transporter HlyB
N Hanekop et al.
FEBS LETTERS (2006)
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice
J Wang et al.
JOURNAL OF LIPID RESEARCH (2006)
Liver transplantation in a patient with sitosterolemia and cirrhosis
TA Miettinen et al.
GASTROENTEROLOGY (2006)
Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump
R Kubitz et al.
JOURNAL OF CLINICAL GASTROENTEROLOGY (2006)
A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2
CW Lam et al.
JOURNAL OF HEPATOLOGY (2006)
P-glycoprotein recognition of substrates and circumvention through rational drug design
Thomas J. Raub
MOLECULAR PHARMACEUTICS (2006)
The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins
AE van Herwaarden et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: A comparison of human BSEP with rat Bsep
H Hayashi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
J Müller et al.
BIOCHEMICAL PHARMACOLOGY (2005)
New insights into the drug binding, transport and lipid flippase activities of the P-glycoprotein multidrug transporter
FJ Sharom et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2005)
PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots
K Terasaka et al.
PLANT CELL (2005)
Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
K Kopplow et al.
MOLECULAR PHARMACOLOGY (2005)
Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
J Noe et al.
JOURNAL OF HEPATOLOGY (2005)
A nuclear receptor-mediated choleretic action of fibrates is associated with enhanced canalicular membrane fluidity and transporter activity mediating bile acid-independent bile secretion
T Nishioka et al.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2005)
ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects
K Miwa et al.
CLINICAL SCIENCE (2005)
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
HU Marschall et al.
GASTROENTEROLOGY (2005)
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
M Hirano et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)
SV Ambudkar et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2005)
Functional characterization and ATP-induced dimerization of the isolated ABC-domain of the haemolysin B transporter
J Zaitseva et al.
BIOCHEMISTRY (2005)
Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion
P Tietz et al.
JOURNAL OF LIPID RESEARCH (2005)
The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease
CC Paulusma et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)
Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells
W Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB
J Zaitseva et al.
EMBO JOURNAL (2005)
ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy
R Müllenbach et al.
GUT (2005)
Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception
N Zelcer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2
K Letschert et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11
H Hayashi et al.
HEPATOLOGY (2005)
Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
RAMH Van Aubel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice
JK Kruit et al.
GASTROENTEROLOGY (2005)
Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
JJ Eloranta et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Insulin secretagogues, sulfonylurea receptors and K-ATP channels
J Bryan et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene
D Jung et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)
The complexities of hepatic drug transport: Current knowledge and emerging concepts
P Chandra et al.
PHARMACEUTICAL RESEARCH (2004)
ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
K Kajinami et al.
JOURNAL OF LIPID RESEARCH (2004)
Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat
GU Denk et al.
JOURNAL OF HEPATOLOGY (2004)
Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP)
J Koch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion
JL Lew et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis
C Pauli-Magnus et al.
HEPATOLOGY (2004)
Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) gene
PLR Ee et al.
CANCER RESEARCH (2004)
Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients
N Roglans et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy
C Pauli-Magnus et al.
PHARMACOGENETICS (2004)
Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase
R Kubitz et al.
GASTROENTEROLOGY (2004)
Organic anion transporting polypeptides of the OATP/SLC21 family:: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
B Hagenbuch et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
The ATP switch model for ABC transporters
CF Higgins et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity
H Gylling et al.
JOURNAL OF LIPID RESEARCH (2004)
Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11
SWC Van Mil et al.
GASTROENTEROLOGY (2004)
Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells
DF Ortiz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function
P Natarajan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Disposition mechanisms of raloxifene in the human intestinal Caco-2 model
EJ Jeong et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages
T Annilo et al.
GENOMICS (2004)
The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter
LA Freeman et al.
JOURNAL OF LIPID RESEARCH (2004)
Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity
PK Smitherman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking
GA Graf et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Enterohepatic bile salt transporters in normal physiology and liver disease
GA Kullak-Ublick et al.
GASTROENTEROLOGY (2004)
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process
MGL Elferink et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol
Eric L. Klett et al.
BMC MEDICINE (2004)
Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARα-mediated redistribution of ABCB4
J Shoda et al.
JOURNAL OF LIPID RESEARCH (2004)
Hepatic P-glycoprotein changes with total parenteral nutrition administration
Y Tazuke et al.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2004)
Farnesoid X receptor activates transcription of the phospholipid pump MDR3
L Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3
CJ Westlake et al.
BIOCHEMISTRY (2003)
P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo
O van Tellingen et al.
BRITISH JOURNAL OF CANCER (2003)
Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins
T Fehrenbach et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2003)
P-glycoprotein: from genomics to mechanism
SV Ambudkar et al.
ONCOGENE (2003)
Role of carboxylate residues adjacent to the conserved core walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1)
LF Payen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle
J Chen et al.
MOLECULAR CELL (2003)
The ATP/Substrate stoichiometry of the ATP-binding cassette (ABC) transporter OpuA
JS Patzlaff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits
KW Chan et al.
EMBO JOURNAL (2003)
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
M Rius et al.
HEPATOLOGY (2003)
The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p
E Janas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells
M Hoekstra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
N Zelcer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
ABCG2 transports sulfated conjugates of steroids and xenobiotics
M Suzuki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis
T Janvilisri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors
RB Wang et al.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2003)
Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells
LM Mangravite et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2003)
Bile salt export pump gene mutations in two Japanese patients with progressive familial intrahepatic cholestasis
K Goto et al.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2003)
Bile salt transporters: Molecular characterization, function, and regulation
M Trauner et al.
PHYSIOLOGICAL REVIEWS (2003)
A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis
JF Lucena et al.
GASTROENTEROLOGY (2003)
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins
T Hegedüs et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis
T Pomorski et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations
F Basso et al.
JOURNAL OF LIPID RESEARCH (2003)
Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3
CJ Oleschuk et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Real-time reverse transcription-PCR expression profiling of the complete human ATP-binding cassette transporter superfamily in various tissues
T Langmann et al.
CLINICAL CHEMISTRY (2003)
Peroxisome proliferator-activated receptor α (PPARα)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
T Kok et al.
BIOCHEMICAL JOURNAL (2003)
Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy
ML Eloranta et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2003)
Transbilayer phospholipid movement and the clearance of apoptotic cells
P Williamson et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)
Functional analysis of candidate ABC transporter proteins for sitosterol transport
C Albrecht et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter -: Modulation of substrate specificity by a point mutation
C Özvegy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
LQ Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Prospective study of liver dysfunction in pregnancy in Southwest Wales
CL Ch'ng et al.
GUT (2002)
The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors
JA Byrne et al.
GASTROENTEROLOGY (2002)
Functional expression of the canalicular bile salt export pump of human liver
J Noé et al.
GASTROENTEROLOGY (2002)
PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator
A Swiatecka-Urban et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The ABCA1 transporter functions on the basolateral surface of hepatocytes
EB Neufeld et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I
ML Fitzgerald et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer
PC Smith et al.
MOLECULAR CELL (2002)
Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
A Enomoto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)
A Iliás et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The E-coli BtuCD structure:: A framework for ABC transporter architecture and mechanism
KP Locher et al.
SCIENCE (2002)
MRP6 (ABCC6) detection in normal human tissues and tumors
GL Scheffer et al.
LABORATORY INVESTIGATION (2002)
Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
H Kimura et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
M Sasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Drugs as P-glycoprotein substrates, inhibitors, and inducers
RB Kim
DRUG METABOLISM REVIEWS (2002)
FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels
HL Chen et al.
JOURNAL OF PEDIATRICS (2002)
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) rnRNA and hepatic induction of mrp3 by constitutive androstane receptor activators in rats
NJ Cherrington et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
YH Cui et al.
MOLECULAR PHARMACOLOGY (2001)
A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gating
J Fu et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
A spectrum of ABCC6 mutations is responsible for pseudoxanthoma elasticum
O Le Saux et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
S Zhou et al.
NATURE MEDICINE (2001)
The crystal structure of the MJ0796 ATP-binding cassette - Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter
YR Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Two genes that map to the STSL locus cause sitosterolemia:: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
KM Lu et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
MG Donner et al.
HEPATOLOGY (2001)
Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1
SR Hamilton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
C Özvegy et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter
N Karpowich et al.
STRUCTURE (2001)
The human ATP-binding cassette (ABC) transporter superfamily
M Dean et al.
GENOME RESEARCH (2001)
The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood
E Jacquemin et al.
GASTROENTEROLOGY (2001)
Purification and characterization of N-glycosylation mutant mouse and human P-glycoproteins expressed in Pichia pastoris cells
IL Urbatsch et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Genetic basis of sitosterolemia
MH Lee et al.
CURRENT OPINION IN LIPIDOLOGY (2001)
Organic anion-transporting potypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
GA Kullak-Ublick et al.
GASTROENTEROLOGY (2001)
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
MH Lee et al.
NATURE GENETICS (2001)
FIC1 disease: A spectrum of intrahepatic cholestatic disorders
SWC van Mil et al.
SEMINARS IN LIVER DISEASE (2001)
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
KE Berge et al.
SCIENCE (2000)
ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
JF Oram et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1
N Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping
AJ Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosis
N Kinnman et al.
HEPATOLOGY (2000)
Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes
S Gupta et al.
HEPATOLOGY (2000)
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
J König et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum
O Le Saux et al.
NATURE GENETICS (2000)
Molecular cloning and characterization of the murine bile salt export pump
RM Green et al.
GENE (2000)
Short-term regulation of canalicular transport
D Haussinger et al.
SEMINARS IN LIVER DISEASE (2000)
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
J Konig et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
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