4.4 Review

Recent Progress in Boosted PDT Induced Immunogenic Cell Death for Tumor Immunotherapy

Journal

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
Volume 37, Issue 1, Pages 83-89

Publisher

HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-021-0402-5

Keywords

Photodynamic therapy; Immunogenic cell death; Damage-associated molecular pattern

Funding

  1. National Natural Science Foundation of China [51873092, 51961160730, 31900983]
  2. National Key R&D Program of China(Intergovernmental Cooperation Project) [2017YFE0132200]
  3. Fundamental Research Funds for the Central Universities of China
  4. Tianjin Science Fund for Distinguished Young Scholars, China [19JCJQJC61200]

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With the rapid development of materials science, photosensitive materials play an important role in immunogenic cell death (ICD) by inducing reactive oxygen species (ROS) generation under light irradiation. Studies on photodynamic therapy (PDT) induced ICD have shown promising results in cancer immunotherapy, offering various strategies for researchers to explore.
With the rapid development of materials science, photosensitive materials have been widely used in the field of immunogenic cell death(ICD), which was on account of the reactive oxygen species(ROS) generation by photosensitizer under light irradiation inducing cellular oxidative stress during the dying of cells. Considerable researches related to photodynamic therapy(PDT) induced ICD were conducted and exhibited brilliant performance in cancer immunotherapy. Herein, a variety of different strategies for PDT induced ICD have been summarized and discussed to provide researchers more inspiration for cancer immunotherapy.

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