Journal
CHEMICAL ENGINEERING JOURNAL
Volume 417, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.127989
Keywords
Tellurium nanorods; Polypeptide-engineered; Photothermal therapy; Sonodynamic therapy; Tumor
Categories
Funding
- National Key Research and Development Program of China [2018YFE0113400]
- National Natural Science Foundation of China [81871414, 81771878, 81971658, 91959109]
- China Postdoctoral Science Foundation [2017M612462]
- Fundamental Research Funds for the Central Universities [2016YXMS253, 2017KFXKJC002, 2018KFYXKJC048]
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The study successfully synthesized genetically engineered polypeptide-capped tellurium nanorods, demonstrating great potential for tumor therapy. The P-TeNRs showed excellent photothermal and reactive oxygen species generation capabilities under near-infrared laser and ultrasound irradiation, enabling combined photothermal and sonodynamic therapy for tumors.
Nanoparticles containing elemental tellurium (Te) have been aroused extensive attention in biomedical applications. However, the ideal synthesis methods and effective anti-cancer strategies of Te nanoparticles remain great challenges. In this study, genetically engineered polypeptide (PC(10)ARGD)-capped Te nanorods (P-TeNRs) was in situ synthesized. The excellent dispersion of P-TeNRs with average lengths of 25.2 +/- 4.65 nm and diameters of 6.5 +/- 0.83 nm were confirmed by TEM. PC(10)ARGD was integrated onto the surface of Te nanorods to enhance the stability and biocompatibility of P-TeNRs. P-TeNRs exhibited the excellent photothermal conversion performance under irradiation of NIR laser and the reactive oxygen species (ROS) generating capacity under ultrasound (US) irradiation, which can achieve photothermal therapy and sonodynamic therapy of tumors. Compared with single photothermal therapy and sonodynamic therapy, the results of in vitro and in vivo experiments showed that the combination therapy has a synergistic effect on breast 4T1 tumors. In addition, the results of in vivo toxicity assay suggested that synthesized P-TeNRs presented negligible toxicity. These results demonstrate that this P-TeNRs can be engineered as a novel theranostic nanoplatform for synergistic photothermal-sonodynamic therapy of tumors.
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