Journal
CHEMCATCHEM
Volume 13, Issue 1, Pages 212-216Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202001742
Keywords
late stage cyanation; micellar catalysis; Pd catalyzed cross coupling; aryl halides; aryl nitriles
Categories
Funding
- PHT International
- NSF [CHE 18-56406]
- Novartis
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The new technology enables efficient cyanation reactions of highly complex molecules in water, with significant implications for advancing drug synthesis and discovery.
New technology is described that enables late stage ppm Pd-catalyzed cyanations of highly complex molecules, as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a commercially available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent.
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